Increase in Life-Threatening Invasive Fungal Infections in France

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The incidence of life-threatening invasive fungal (mold) infections has been growing in recent years. Persons at high risk for invasive fungal infections include those with immunocompromised immune systems, such as those with HIV, severe malnutrition, immunosuppressive drugs for bone or organ transplants, and certain forms of cancer like leukemia or lymphoma. 

Dounia Bitar et al. Population-based analysis of invasive fungal infections, France, 2001-2010.

However, the rates of invasive fungal infections have also been growing among people without compromised immune systems.

Analysis was made of invasive fungal infections occurring in French hospitals between 2001 and 2010 (Population of France is about 63 million in 2014). Over this 10 year period, the annual rate of invasive fungal infections increased by 16% and the annual rate of deaths from invasive fungal infections grew by 33%. During these 10 years, fungi caused 35,876 hospital infections and 9,889 deaths. Total numbers of invasive hospital infections caused by various fungi in this 10 year period were 15,559 for Candida, 9,365 for Pneumocystis, 8,563 for Aspergillus, 1,859 for Cryptococcosis, and 530 for Mucormycosis.

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