New Treatments/ Preventive Measures For Fungal Infections

luke-curtis
The effects of fungal infections are greatly underestimated.  Every year about one quarter of humans develop some sort of fungal infection.  Invasive fungal infections – especially from four genera- Candida, Aspergillus, Cryptococcus, and Pneumocystis– cause an estimated 1.5 million worldwide annual deaths 1-3.


Three classes of anti-fungal drugs currently exist 1 : 

1.  Polyene drugs such as Amphotericin B.
2. Azole drugs such as voriconazole, fluconazole, itraconazole, ketoconazole, and posaconazole.
3. The newly developed echinocanadin drugs such as caspofungin and micafungin.

All of these drugs have difficulties due to lack of coverage for all fungi and the development of fungal resistance in fungi that were previously treatable by the drug.  Some of these antifungal drugs- such as amphotericin B- also have serious problems with toxicity side effects.

Clearly, new treatments for fungal infections are needed.  Several new promising fungal treatments/ preventive measures include vaccines, Blad containing oligomers, and dihyroorotate dehydrogenase inhibitors.  These new treatments are described briefly below:

 {module FL-VOL1}


Vaccines- No clinically available vaccines currently exist for fungal diseases
2. Mouse studies using live, attenuated fungi such as Blastomyces dermatititidus and Cryptococcus neoformans have shown promising results 2. Some human studies involving formaldehyde killed spherules of Coccidioides immitis or recombinant Candida albicans proteins have been somewhat promising 2 

Blad Containing Oligomers.  These chemicals are derived from the Lupinus (lupine) plant.  These Blad Containing oligomers are able to inhibit growth of Candida albicans by alteration of metal metabolism and by causing apoptotic cell death3. 

Dihydroorotate Dehydrogenase Inhibitors-  Recently, a new antifungal drug F901318 has been discovered which has strong inhibitory effects on many Aspergillus species including Aspergillus fumigatus, flavus, niger and terreus but does not seem very toxic to human cells.  These drugs block Aspergillus growth by inhibiting the enzyme dihydroorotate dehydrogenase which is involved in fungal DNA synthesis.

 

 

References / Sources

1. Oliver JD, Sibley GE, Beckmann N, et al. F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase. Proc Natl Acad Sci U S A. 2016.

2Armstrong-James D, Brown GD, Netea MG, et al. Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infect Dis. 2017.

3. Pinheiro AM, Carreira A, Prescott TAK, Ferreira RB, Monteiro SA. Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi. Frontiers in microbiology. 2017;8:1182.

 

{flike}
 

Related Articles and videos
{module Related Articles}

{fcomments}

Share on facebook
Share on Facebook
Share on reddit
Share on Reddit
Share on email
Share via Email
Share on twitter
Share on Twitter

Leave a Reply

Recent Articles

Featured Sponsor

Watch Us

Follow Us

Doug's Books

Doug Kaufmann has written many books that cover a full range or health issues. Find out which of his books best suits you by clicking the button below.

The Kaufmann Diet

Doug Kaufmann developed his diet after years studying the clinical effects of pathogenic fungi on the body. Fungi and yeasts can become parasitic organisms on and inside our body, causing health problems that can be difficult to diagnose. Learn more about the Kaufmann Diet, change your life and know the cause.

The Science of Fungus

We encourage all visitors to this site to take some time and study these technical articles prior to initiating lifestyle changes, including dietary changes and to do so with their physician’s awareness and approval. The articles posted in this link are scientific and with few exceptions are taken from medical journals familiar to healthcare workers.

Our Healthy Recipes

Looking for help assembling antifungal Kaufmann Diet approved recipes for breakfast, lunch or dinner? We have several videos, books and recipe write ups here on Know the Cause that will help your health journey. The recipes in this section are so good, you’ll feel like you’re indulging. No sacrifice needed! Enjoy.

Sign-up for our newsletter and get the latest content from Know the Cause.