|In the past several decades there has been a large increase in the number of invasive infections caused by Fusarium molds (fusariosis). Fusarium is a common mold (fungus) which often infects crops such as grains and fruits and produces a large number of toxins (mycotoxins) such as trichothecene and fumonisin mycotoxins.|
J Guarro. Fusariosis, a complex infection caused by a high diversity of fungal species refractory to treatment. European Journal of Clinical Microbiology and Infectious Disease. 2013; In Press
Macio Nucci et al. Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil. Emerging Infectious Diseases October 2013;19(10)1567-72.
Invasive Fusarium infections have a 50-90% mortality rate. Invasive Fusarium infections are most common in immunocompromised patients (HIV, some cancers, bone and organ transplants). However, rates of invasive Fusarium are growing rapidly even among non-immunocompromised patients. Invasive Fusarium infections are difficult to treat, with standard antifungal drugs such as amphotericin B and voriconazole offering only modest efficacy.