Glucose Stimulates Candida Growth

Science of Fungus

(1) Candida problems are generally worse in patients with diabetes. That may be because glucose is such a good substrate for Candida growth. Glucose is found in many carbohydrates in free or polymer form while fructose is especially rich in fruits and high fructose corn syrup. Sucrose or table sugar is 50% glucose and 50% fructose. High fructose corn syrup may be over 50% fructose.

Recently a Romanian study measured laboratory growth of Candida albicans in the presence of 100 to 1,000 milligrams per deciliter of glucose or fructose.

Presence of glucose was related to greatly increased growth rate and significantly reduced the generation time of Candida while fructose had relatively little effect on Candida growth and significantly increased the generation time of Candida. In the presence of glucose- the generation time of Candida can be as little as 87 to 92 minutes.


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Limiting refined carbohydrates containing glucose may be useful for patients with Candida related problems. On the negative side, diets rich in fructose can increase insulin resistance, increase fat synthesis, increase intra-abdominal fat, increase metabolic syndrome risk, increase uric acid and possibly increase weight gain. Blood sugar control is also important in controlling Candida related conditions. It is important to limit the amount of refined sugars in the diet (sugar, corn syrup, honey, fruit juice) and concentrate on eating fiber-rich foods such as fresh vegetables, whole fruits, seeds, and nuts.

References / Sources:

1. Dornas WC, de Lima WG, Pedrosa ML, Silva ME. Health implications of high-fructose intake and current research. Advances in nutrition (Bethesda, Md). 2015;6(6):729-37.

2. Adrian Man1, Cristina Nicoleta Ciurea2, Dan Pasaroiu 2, Ana-Ioana Savin2, Felicia Toma1,4, Floredana Sular3,4, Luigi Santacroce5/+, Anca Mare1 New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 112(9): 587-592, September 2017 587 online | memorias.ioc.fiocruz.br doi: 10.1590/0074-02760170098 + Corresponding author: luigi.santacroce@uniba.it Received 11 March 2017 Accepted 15 April 2017

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