Aspergillus infections are major menaces to immunocompromised patients such as those on immunosuppressive drugs, organ or bone marrow transplants, HIV+, many cancers, and severe malnutrition. Some US estimates place the number of fatalities due to Aspergillus infections at about 5,000 per year- but many researchers suggest that this a severe underestimate due to many undiagnosed cases of Aspergillus.
A study of 67 Mayo Clinic patients who died with autopsy diagnosed fatal Aspergillus reported that only 27%- were correctly diagnosed pre-mortem (1). In other words, almost ¾ of pulmonary Aspergillus cases were not diagnosed before death. They state that “our data combined with previous studies suggest that invasive Aspergillus remains a difficult disease to diagnose even in the presence of recognized risk factors”. Clinicians need to have a strong suspicion for Aspergillus in hospitalized patients and promptly order fungal tests and treatments.
Post-Script by Doug Kaufmann
I believe that millions of people die of “cancer” and many other illnesses that stem from Aspergillus fungus. We know that 2 species of Aspergillus make a carcinogenic byproduct that humans are very commonly exposed to in our food supply and air.
1. Mudrakola HV, Tandon YK, DeMartino E, Tosh PK, Yi ES, Ryu JH (2022): Autopsy study of fatal invasive pulmonary aspergillosis: Often undiagnosed premortem. Respir Med 199, 106882