|Many studies have linked indoor mold exposure with increased risk of asthma. The Quansah et al meta-analysis of 16 published studies on asthma and mold (11 cohort and 5 incident case-control) reported significantly higher rates of asthma which were related to dampness (EE 1.33, 95% CI 1.12-1.56), visible mold (EE 1.29, 1.04-1.60), mold odor 1.73 (1.19-2.50), and any mold or dampness exposure (EE 1.50, 95 CI 1.25-1.80) (Quansah R 2012).|
Severe asthma with fungal sensitization (SAFS) is an increasingly common diagnosis which is seen in about 4-8% of adult asthmatics with a potential worldwide total among children and adults of over 6.5 million (Denning 2015, Overton, Simpson et al. 2017).
SAFS seems to have a strong genetic component, with one UK study of 47 SAFS patients, 279 healthy controls, and 152 atopic asthmatic subjects reporting that SAFS is significantly associated with a number of genes compared with atopic asthma including Toll-like receptor 3 (TLR3)(p=.009),TLR9 (p=.025), C-type lectin domain family seven member A (dectin-1) (p=.043), interleukin-10 (IL-10) (p=.0010), mannose-binding lectin (MBL2)(p=.007), CC-chemokin ligand 2 (CCL2)(p =.025), CCL (p=.002), plasminogen (p=.049) and adenosine A2a receptor (p=.024) (Overton, Simpson et al. 2017
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