Lactobacillus Bacteria Inhibit Candida Albicans Biofilm Development

Many studies have reported that consuming the “probiotic” Lactobacillus bacteria is associated with many health benefits, including less Candida growth in the mouth and GI tract, less Candida vaginitis, reduced irritable bowel syndrome symptoms, and reduced risk of bacterial infections such as Clostridium difficle.   

Victor Matsubara et al. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Applied Microbiology and Biotechnology 2016, In Press

Recent research has found that Lactobacillus can inhibit the growth of Candida in several different ways. Candida can exist either in a free-cell or planktonic form or in a hyphal or biofilm form in which Candida cells form chain liked structures of many cells. Candida biofilms can grow on inanimate surfaces like basins or catheters or on living tissue like the skin, GI tract or the urinary, and sexual organs.

The Candida biofilm or hyphal form produces much larger quantities of toxins and is much more resistant to antibiotics and white blood cells as compared to the free-living or planktonic form of Candida. A laboratory study measured the effects of several species of Lactobacillus- including Lactobacillus rhamnosus, casei, and acidophilus on Candida biofilm growth.

All three species were found to significantly reduce growth of Candida biofilms and all three species significantly reduced Candida differentiation from the free form to the more pathogenic biofilm form.



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