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Does Yeast Cause Antibiotic Resistance?

Does Yeast Cause Antibiotic Resistance
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In 2016, I was honored when being asked to speak to a group of physicians about the role of fungus in “refractory” (unaffected by treatment) infections.   Physicians are taught little about fungal infections, so I used this opportunity to teach them what medical training had not taught them. Yes, fungal infections cause fevers and elevated white blood cell (WBC) counts, just like bacterial infections. I bring this to your attention, because a new study on sciencedaily.com indirectly highlighted this same issue.

The headline, Microbial Study Reveals Extended Lifespan of Starved Bacteria, addressed the problem of chronic infections and how bacteria resist being killed by antibiotics. This study concludes that many infections are difficult to treat and while I concur, I’ve got to wonder if treating with an antifungal drug might reduce that difficulty significantly. When doctors hear the word “infection,” they think “bacteria.” This simply is not the case. In my 2016 lecture, I provided information on a study that demonstrated that when the bacteria Staphylococcus aureus was incubated in a test tube with the yeast, Candida albicans, the bacteria, a drug of last hope in curing resistant Staphylococcus aureus patients, Vancomycin, was ineffective.

Why is this important? Most physicians disagree with me, but I believe that many and perhaps most infections are “co-infections” being both bacterial and fungal in nature. Physicians most always prescribe antibiotics for infected patients hoping that the offending germ is bacterial. Many are, but more and more, antibiotic resistant infections are being diagnosed. This study likely provides data that every physician should learn. From 2017-2021, the Center For Disease Control (CDC) taught doctors to “think fungus” when the drugs they were prescribing were not working. I doubt that our doctors comprehend the magnitude of fungal infections today, so we, the people, must talk to them when our infections persist, despite antibiotics.

References

American Society for Microbiology: Commensal Protection of Staphylococcus aureus against Antimicrobials by Candida albicans Biofilm Matrix | mBio (asm.org)

 

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