|Patients with compromised immunosystems- such as those with HIV, leukemia, lymphoma, severe malnutrition, or on immunosuppressive drugs for bone or organ transplant- are at high risk for invasive pulmonary aspergillosis (ie. Infection with Aspergillus fungi).
Aerosolized Amphotericin B May Be Helpful to Reduce Risk of Invasive Pulmonary Aspergillosis in Immunocompromised Patients
Between 2 to 20% of bone and organ transplant patients develop invasive aspergillosis. Even with intensive treatment with antifungal drugs- invasive pulmonary aspergillosis is fatal about 60% of the time. It is often difficult to diagnose invasive pulmonary aspergillosis in its early and more treatable stage. Therefore, effective prophylactic antifungal treatments are badly needed for immunocompromised patients.
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