Occupational Airborne Exposure To Aflatoxins Related To Lung Cancer

Aflatoxins are mycotoxins produced by certain species of common Aspergillus fungi (molds). Aflatoxins are some of the most carcinogenic (cancer-causing) compounds known and aflatoxin exposure is strongly linked to aflatoxin exposure. Alfatoxins frequently contaminate staple crops like peanuts, corn (maize), and other grains and legumes.  

Hao Lai et al., Association between aflatoxin B1 occupational airway exposure and risk of hepatocellular carcinoma: a case-control study.

Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental Health Perspectives 2010;118:88-24.

Foodborne exposure to aflatoxins is estimated to cause 25,500 to 155,000 worldwide cases of liver cancer per year.

Occupational airborne exposure to aflatoxins has been linked to significantly increased rates of liver cancer. A Chinese study reported that serum blood albumin aflatoxin B1 adducts were found in 57 of 102 (56%) sugar and paper industry workers who developed liver cancer were exposed to airborne aflatoxins, but in only 12 out 150 (8%) unexposed controls (p<0.001).

Airborne exposure to aflatoxin contaminated dust was significantly associated with the risk of developing liver cancer (OR 5.24, 95% CI 2.77-9.88)


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