Mold Lung Colonization Associated With Asthma

Asthma is a complex disease which affects rough 5 to 10% of children and adults worldwide. There are many known environmental triggers to asthma including particulates, ozone, pesticides, solvents, pollen, and mold spores.

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Giovanna Carpagnano et al. Analysis of the fungal microbiome in exhaled breath condensate of patients with asthma. Allergy and Asthma Proceedings 2016;37:e37-e46, doi : 10.2500/aap.2016.37.3943.

Eating food allergens and the presence of chronic Candida yeast infections can also increase asthma risk. Presence of bacterial and viral infections/ colonizations in the lung (such as the RSV and influenza viruses) have also been associated with increased risk of asthma. The presence of fungal infections/ colonizations in the lung can also significantly increase the risk of asthma. An Italian study reported that culturable fungi was found in the exhaled breath condensate in 29 of 47 (70%) patients with asthma but 0 of 20 (0%) health controls. Among the 29 asthma patients with asthma in exhaled breath- 94% had culturable Cladosporium, 24% had culturable Penicillium, and 21% had culturable Alternaria. More research is needed to examine possible relationships between lung fungal infections/ colonizations and asthma.

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