|SINUS PROBLEMS, CHRONIC FATIGUE, AND DEFICIENCY OF GROWTH HORMONE AND OTHER PITUITARY HORMONES.
Chronic sinus problems are present in 10 to 15% of the child and adult population in the USA. About 200,000 sinus surgeries are performed annually in the USA. Sinus problems are often related to growth of molds (fungi) in the nasal passages and/or to exposure to high levels of indoor molds.
Donald Dennis, David Robertson, Luke Curtis, and Judson Black. Fungal exposure endocrinopathy in sinusitis with growth hormone deficiency: The Dennis-Robertson Syndrome. Toxicology and Industrial Health 2009;25:669-680.
Various studies of chronic sinus patients report growth of mold and/or mold fragments found in the sinus mucous in 75% to 100% of all chronic sinusitis patients. Chronic sinusitis patients often experience chronic fatigue, asthma, and many other chronic health problems.
This study suggests that mold related sinusitis may be a major cause of both growth hormone and thyroid hormone deficiency. The exact mechanism in which mold and mycotoxin exposure can damage the pituitary gland is not known. One hypothesis is that the lenticulostellate cells of the anterior pituitary gland bind to the fungal cell walls, activate the innate immune system, and stimulate macrophages (white blood cells) which destroy both the fungi and the pituitary gland. The damage to the pituitary gland can then significantly reduce production of both growth hormone and thyroid hormone.