Chronic disease affects about 133M Americans and within the next 18 months, that number should hit 157M, with 81M having multiple conditions! In 2009, 70% of deaths were due to chronic diseases. In 2007, it was reported that 7 chronic diseases (heart disease, cancer, diabetes, hypertension, stroke, mental diseases and lung diseases) have a total impact on the American economy of $1.3T. in 4-5 years, this number, including lost economic output, is expected to increase to $4.2T WebMD - June 29, 2011 - More than 100 million Americans suffer from chronic pain at a cost of around $600 billion a year in medical treatments and lost productivity, according to a report from the Institute of Medicine (IOM).